![]() ![]() Significant decrease in the Melasma Area and Severity Index (MASI) score with no significant side effects was seen after 8 weeks of microinjection of TA. The result of a clinical trial of localized microinjection of TA proved to be promising. Therefore, the anti-plasmin activity of TA is thought as the main mechanism of hypopigmentory effect of this agent. These two substances can activate melanin synthesis. The intracellular release of arachidonic acid (AA), a precursor of prostanoid, and the level of alpha-melanocyte-stimulating hormone increase as the result of plasmin activity. In recent times, some researchers found that tranexamic acid (TA), a traditional hemostatic drug, has hypopigmentory effect on melasma lesions and also prevents UV-induced pigmentation. Usually, bleaching agents are prescribed in combination with other therapies, such as tretinoin, topical corticosteroids, or superficial peeling agents. These factors include photo-induced hormones, growth factors, and chemical and inflammatory mediators.ĭifferent treatment modalities which include elimination of any possible causative factors, use of sunscreen, hypopigmenting agents, and laser therapy are used. Moreover, some factors influence the function of melanocytes, so they can contribute to the UV-induced pigmentation. Although the precise cause of melasma remains unknown, some factors such as genetic susceptibility, ultraviolet (UV) light exposure, pregnancy, sex hormones, contraceptive pills, thyroid disease, cosmetics, phototoxic drugs (e.g., antiseizure medications) have been identified as some common contributing factors in developing melasma. Men represent only 10% of cases however, the clinicohistologic characteristics of the disease are same in both sexes. This disease is commonly observed in women. Many skincare professionals find that combining multiple effective ingredients into one cream is the best way for patients to stay compliant with treatment and improve their melasma.Melasma is a common acquired dermatitis of light to dark brown macules and patches involving the sun-exposed areas of the face and neck. It is difficult to find a melasma treatment that really works. We are able to offer higher percentages of hydroquinone than are commercially available in these combinations. ![]() Multiple strengths and ingredients are available depending on the severity of the patient’s melasma and their skin type. Unlike commercially available products, our creams can be custom formulated based on the unique needs of each patient. When these ingredients are used together they provide a greater improvement in melasma than when used alone. Hydrocortisone is included as an anti-inflammatory that soothes the skin to prevent irritation while the other ingredients work. Tretinoin clears the skin of blemishes and discolorations by increasing cell turnover. Hydroquinone and kojic acid are lightening agents that reduce hyperpigmentation. Several effective ingredients are included in this cream for treating melasma. When used as part of the kit, the cream is applied daily after the in-office application of the melasma mask. It is comparable to the Cosmelan 2 (Cos 2) Cream included in the original European Cosmelan Kit with hydroquinone. This melasma maintenance cream is part of our Melasma Kit and contains effective, prescription-strength ingredients for reducing melasma pigmentation. ![]()
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